Medisinen ble opprinnelig utviklet i Frankrike til bruk i det franske forsvaret. Den skulle brukes av det franske flyvåpenets soldater, slik at de skulle føle mindre tretthet og klare å konsentrere seg bedre om oppgavene sine.
modafinil will minimize the level or influence of fruquintinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. If coadministration with average CYP3A4 inducers is unavoidable, keep on to administer fruquintinib at recommended dosage.
This research reviewed the importance of psychoactive drugs, and talked over the benefits and pitfalls of the appliance of modafinil, which appears to be perfect as an anti-psychotic or anti-fatigue agent.
It should be applied with warning in individuals with uncontrolled hypertension, unstable angina, or new myocardial infarction.
stiripentol will increase the degree or effect of modafinil by impacting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Monitor Closely. Look at minimizing the dose of CYP2C19 substrates, if adverse reactions are skilled when administered concomitantly with stiripentol.
[34] GABA provides a calming and calming impact that is certainly needed for sleep, and diminished degrees are believed to Engage in a task in Modafinil’s eugeroic impact.
modafinil will increase amounts of eluxadoline by impacting hepatic enzyme CYP2C19 metabolism. Use Caution/Check. To be a precautionary measure on account of incomplete info on the metabolism of eluxadoline, use caution when coadministered with sturdy CYP2C19 inhibitors.
Danger of skin reactions, Steven-Johnsons Syndrome, harmful necrolysis, and drug rash with eosinophilia and systemic signs; discontinue if rash or other hypersensitivity reactions website happen
Additionally, Cephalon entered agreements with several generic drug companies to delay the sale of generic modafinil inside the US.
Considerable clinical investigation has not demonstrated drug tolerance as a typical adverse effect, Despite therapeutic use extending as much as forty weeks.
apalutamide will lessen the extent or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with medications which are CYP3A4 substrates can result in decreased exposure to those medicines.
Stay clear of or substitute A further drug for these medicines when probable. Consider for loss of therapeutic effect if medication should be coadministered. Adjust dose In accordance with prescribing info if desired.
itraconazole will boost the degree or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
Pregnancy: It is classed as pregnancy class C medication because of the FDA. There's no proof to advise or exclude harm towards the human fetus linked to modafinil.